Substance P

Definition

Substance P is a neuropeptide involved in the transmission of pain signals to the central nervous system. It binds primarily to the neurokinin-1 (NK1) receptor, playing a crucial role in pain perception.

5 Must Know Facts For Your Next Test

1. Substance P is released from sensory nerve endings in response to noxious stimuli.
2. It is associated with inflammatory processes and can contribute to chronic pain conditions.
3. Antagonists of substance P are being studied for their potential in treating pain and depression.
4. Substance P can also influence other physiological processes like mood, anxiety, and nausea.
5. It works by binding to NK1 receptors, which are found in both the peripheral and central nervous systems.

Review Questions

• What role does substance P play in the transmission of pain signals?
• How does substance P contribute to chronic pain conditions?
• What receptor does substance P primarily bind to?

Related terms

Neurokinin-1 (NK1) Receptor: A receptor that binds substance P and mediates its effects.

Nociceptor: A sensory receptor for painful stimuli.

Neuropeptide: A small protein-like molecule used by neurons to communicate with each other.