Stevens–Johnson syndrome

Definition

Stevens–Johnson syndrome (SJS) is a severe skin and mucous membrane reaction, often triggered by medications. It involves painful blistering and can be life-threatening.

5 Must Know Facts For Your Next Test

1. SJS can be triggered by drugs used to treat Alzheimer's disease, such as certain antiepileptics.
2. Early symptoms include flu-like signs, followed by a painful red or purplish rash that spreads and blisters.
3. Urgent discontinuation of the offending drug is critical in managing SJS.
4. Supportive care in an intensive care unit or burn center is often required for severe cases.
5. SJS may lead to long-term complications such as chronic pain, eye problems, and secondary infections.

Review Questions

• What are common initial symptoms of Stevens–Johnson syndrome?
• How should Stevens–Johnson syndrome be managed if suspected due to medication?
• What long-term complications can arise from Stevens–Johnson syndrome?

Related terms

Toxic Epidermal Necrolysis (TEN): A more severe form of Stevens–Johnson syndrome with greater than 30% body surface area involvement.

Antiepileptics: Medications often associated with triggering Stevens-Johnson Syndrome.

Mucous Membrane: The moist lining of some organs and body cavities, including the mouth, nose, eyes, and genitals; affected in SJS.