Serotonin norepinephrine reuptake inhibitors (SNRIs)

Definition

Serotonin norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressants that increase the levels of serotonin and norepinephrine in the brain by inhibiting their reabsorption (reuptake) into neurons. They are commonly prescribed for major depressive disorder, anxiety disorders, and certain chronic pain conditions.

5 Must Know Facts For Your Next Test

1. SNRIs include medications such as venlafaxine, duloxetine, and desvenlafaxine.
2. Common side effects of SNRIs can include nausea, dry mouth, dizziness, insomnia, and increased blood pressure.
3. SNRIs work by blocking the reuptake pumps for both serotonin and norepinephrine, leading to higher concentrations of these neurotransmitters in the synaptic cleft.
4. Unlike selective serotonin reuptake inhibitors (SSRIs), SNRIs affect both serotonin and norepinephrine neurotransmission.
5. Patients taking SNRIs should be monitored for signs of serotonin syndrome, a potentially life-threatening condition caused by excessive accumulation of serotonin.

Review Questions

• Name two common medications that are classified as SNRIs.
• What are the primary neurotransmitters affected by SNRIs?
• List three common side effects associated with SNRI use.

Related terms

SSRI: Selective Serotonin Reuptake Inhibitors (SSRIs) increase serotonin levels by inhibiting its reuptake into neurons.

Serotonin Syndrome:

A serious condition caused by excessive accumulation of serotonin in the body, often due to drug interactions or overdose.

Neurotransmitter:

Chemical substances that transmit signals across a synapse from one neuron to another.