Selective serotonin reuptake inhibitors (SSRIs)

Definition

Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs used primarily to treat depression by increasing serotonin levels in the brain. They work by blocking the reabsorption (reuptake) of serotonin into neurons, making more serotonin available.

5 Must Know Facts For Your Next Test

1. SSRIs are commonly prescribed for major depressive disorder, anxiety disorders, and some personality disorders.
2. The most frequently prescribed SSRIs include fluoxetine (Prozac), sertraline (Zoloft), and citalopram (Celexa).
3. Common side effects of SSRIs include nausea, insomnia, sexual dysfunction, and dry mouth.
4. SSRIs may take several weeks to show their full therapeutic effects.
5. SSRIs have a lower risk of overdose compared to older classes of antidepressants like tricyclics.

Review Questions

• What is the primary mechanism of action for SSRIs?
• Name three common side effects associated with SSRI use.
• Why might SSRIs be preferred over older classes of antidepressants?

Related terms

Serotonin:

A neurotransmitter that contributes to feelings of well-being and happiness.

Tricyclic Antidepressants (TCAs):

An older class of antidepressant drugs that work by inhibiting the reuptake of norepinephrine and serotonin.

Monoamine Oxidase Inhibitors (MAOIs): A class of antidepressant drugs that prevent the breakdown of monoamine neurotransmitters, thus increasing their availability.