Repatha

Definition

Repatha (evolocumab) is a monoclonal antibody that inhibits PCSK9 and is used to lower LDL cholesterol levels in patients. It is often prescribed for those who have not achieved desired cholesterol levels with statins alone.

5 Must Know Facts For Your Next Test

1. Repatha reduces LDL cholesterol by inhibiting the PCSK9 protein, which increases the number of LDL receptors on liver cells.
2. It is administered via subcutaneous injection, typically every two or four weeks.
3. Repatha is particularly useful for patients with familial hypercholesterolemia or those at high risk of cardiovascular events.
4. Common side effects include nasopharyngitis, upper respiratory tract infections, and injection site reactions.
5. Clinical trials have shown that Repatha can reduce major cardiovascular events such as heart attacks and strokes.

Review Questions

• What mechanism does Repatha use to lower LDL cholesterol?
• How is Repatha administered to patients?
• Name some common side effects associated with Repatha.

Related terms

Statins:

Drugs that inhibit HMG-CoA reductase, an enzyme involved in cholesterol synthesis.

PCSK9 Inhibitors:

Class of drugs that block the PCSK9 protein to increase LDL receptor availability and reduce blood cholesterol levels.

Familial Hypercholesterolemia:

A genetic disorder characterized by high cholesterol levels, particularly very high levels of low-density lipoprotein (LDL).