Propionic acid derivatives

Definition

Propionic acid derivatives are a class of nonsteroidal anti-inflammatory drugs (NSAIDs) commonly used to reduce inflammation and alleviate pain. They work by inhibiting the enzymes COX-1 and COX-2, which are involved in the inflammatory response.

5 Must Know Facts For Your Next Test

1. Common examples include ibuprofen, naproxen, and ketoprofen.
2. They are typically used to treat conditions such as arthritis, muscle pain, and menstrual cramps.
3. Side effects may include gastrointestinal discomfort, ulcers, and increased risk of cardiovascular events.
4. They should be used with caution in patients with renal impairment or those taking other medications that affect kidney function.
5. These drugs can interact with anticoagulants, increasing the risk of bleeding.

Review Questions

• What are common medical conditions treated with propionic acid derivatives?
• Name two enzymes that propionic acid derivatives inhibit to exert their anti-inflammatory effects.
• List three potential side effects associated with the use of propionic acid derivatives.

Related terms

NSAIDs:

Nonsteroidal anti-inflammatory drugs that reduce inflammation and pain without steroids.

COX Inhibitors: Drugs that inhibit cyclooxygenase enzymes to reduce inflammation.

Ibuprofen:

A common propionic acid derivative used for pain relief and reducing inflammation.