Pleiotropic effects

Definition

Pleiotropic effects are additional, non-lipid lowering benefits provided by certain drugs. In pharmacology, these effects can include anti-inflammatory, antioxidant, and vascular benefits.

5 Must Know Facts For Your Next Test

1. Statins exhibit pleiotropic effects that include improving endothelial function and stabilizing atherosclerotic plaques.
2. Pleiotropic effects of statins involve reducing inflammation and oxidative stress in the cardiovascular system.
3. PCSK9 inhibitors primarily lower LDL cholesterol but also have emerging data suggesting pleiotropic cardiovascular benefits.
4. The anti-thrombotic effect of statins is considered one of their pleiotropic benefits.
5. Understanding pleiotropic effects helps clinicians appreciate the full therapeutic potential beyond lipid-lowering.

Review Questions

• What are some examples of pleiotropic effects observed with statin use?
• How do the pleiotropic effects of PCSK9 inhibitors potentially benefit cardiovascular health?
• Why is it important for nurses to understand the pleiotropic effects of lipid-lowering drugs?

Related terms

Endothelial Function:

Refers to the performance and health of the inner lining of blood vessels.

Oxidative Stress:

An imbalance between free radicals and antioxidants in the body.

Atherosclerotic Plaques: Accumulations of fatty deposits within arterial walls that can lead to heart disease.