Misoprostol

Definition

Misoprostol is a synthetic prostaglandin E1 (PGE1) analogue used to prevent gastric ulcers, particularly in patients taking NSAIDs. It works by increasing the production of protective mucus in the stomach lining and reducing stomach acid secretion.

5 Must Know Facts For Your Next Test

1. Misoprostol is often prescribed to prevent NSAID-induced gastric ulcers.
2. It can cause uterine contractions and is contraindicated in pregnancy due to the risk of miscarriage.
3. Common side effects include diarrhea, abdominal pain, and nausea.
4. Misoprostol's mechanism of action involves stimulating prostaglandin receptors to enhance mucosal defense.
5. It is also used off-label for inducing labor and as part of medical abortion regimens.

Review Questions

• What is the primary use of Misoprostol in patients taking NSAIDs?
• Why is Misoprostol contraindicated during pregnancy?
• How does Misoprostol help protect the gastric lining?

Related terms

Prostaglandins:

A group of lipid compounds that have diverse hormone-like effects, including protecting the stomach lining.

NSAIDs (Nonsteroidal Anti-Inflammatory Drugs): Medications commonly used to relieve pain and reduce inflammation but can cause gastric ulcers.

Pepsin Inhibitors:

Drugs that inhibit pepsin activity, which can damage the stomach lining if not regulated.