Langerhans cells

Definition

Langerhans cells are specialized dendritic cells found in the epidermis, playing a crucial role in the skin's immune response. They capture and present antigens to T-cells, initiating an adaptive immune response.

5 Must Know Facts For Your Next Test

1. Langerhans cells originate from bone marrow and migrate to the epidermis.
2. They are involved in the detection of pathogens and foreign substances on the skin.
3. These cells can move to lymph nodes to activate T-cells.
4. Langerhans cells contain Birbeck granules, which are rod-shaped organelles visible under an electron microscope.
5. They play a significant role in dermatologic disorders such as psoriasis and contact dermatitis.

Review Questions

• What is the primary function of Langerhans cells in the epidermis?
• How do Langerhans cells contribute to the skin's immune defense?
• What is the significance of Birbeck granules in Langerhans cells?

Related terms

Dendritic Cells:

Immune cells that process antigen material and present it on their surface to T-cells.

Epidermis:

The outermost layer of skin, providing a barrier to infection.

Antigen-Presenting Cells (APCs):

Cells that display antigens on their surface for recognition by T-cells.