Janumet

Definition

Janumet is an oral antidiabetic medication combining sitagliptin and metformin. It is used to improve glycemic control in adults with type 2 diabetes.

5 Must Know Facts For Your Next Test

1. Janumet combines two antihyperglycemic agents: sitagliptin (a DPP-4 inhibitor) and metformin (a biguanide).
2. Sitagliptin increases insulin production and decreases glucagon levels by inhibiting the enzyme dipeptidyl peptidase-4 (DPP-4).
3. Metformin works by decreasing hepatic glucose production and improving insulin sensitivity in peripheral tissues.
4. Common side effects include gastrointestinal issues like diarrhea, nausea, and stomach pain.
5. Janumet should be taken with meals to reduce the gastrointestinal side effects associated with metformin.

Review Questions

• What are the two active components of Janumet, and what are their respective mechanisms of action?
• Why is it recommended to take Janumet with meals?
• List some common side effects of Janumet.

Related terms

Sitagliptin:

An oral DPP-4 inhibitor used to enhance glycemic control in type 2 diabetes.

Metformin:

A biguanide class drug that reduces hepatic glucose production and increases insulin sensitivity.

Type 2 Diabetes:

A chronic condition characterized by insulin resistance and impaired insulin secretion.