Fluphenazine

Definition

Fluphenazine is a first-generation antipsychotic medication used primarily to treat symptoms of schizophrenia and other psychotic disorders. It works by blocking dopamine receptors in the brain, thereby reducing psychotic symptoms.

5 Must Know Facts For Your Next Test

1. Fluphenazine is commonly administered via intramuscular injection for patients with poor oral compliance.
2. It has a high risk of extrapyramidal side effects (EPS) such as tardive dyskinesia and parkinsonism.
3. Fluphenazine is part of the phenothiazine class of antipsychotics.
4. It can cause severe hypotension and sedation, especially when combined with other CNS depressants.
5. Patients on fluphenazine require regular monitoring for signs of neuroleptic malignant syndrome (NMS), a potentially life-threatening condition.

Review Questions

• What are the primary uses of fluphenazine in psychiatric treatment?
• Name two major side effects associated with fluphenazine.
• How does fluphenazine work to alleviate psychotic symptoms?

Related terms

Chlorpromazine:

Another first-generation antipsychotic used to treat various psychoses.

Tardive Dyskinesia:

A movement disorder caused by long-term use of antipsychotics, characterized by repetitive, involuntary movements.

Neuroleptic Malignant Syndrome (NMS): A rare but serious condition involving muscle rigidity, fever, and autonomic instability, often triggered by antipsychotics.