Farxiga

Definition

Farxiga (dapagliflozin) is an oral medication that belongs to the class of sodium-glucose cotransporter 2 inhibitors (SGLT2Is), used to manage type 2 diabetes and heart failure by promoting glucose excretion through the urine. It helps lower blood sugar levels and reduce the risk of cardiovascular events in patients with heart failure.

5 Must Know Facts For Your Next Test

1. It inhibits SGLT2 in the proximal renal tubules, reducing glucose reabsorption and increasing its excretion.
2. Farxiga is approved for use in patients with type 2 diabetes, chronic kidney disease, and heart failure.
3. It has been shown to reduce the risk of hospitalization for heart failure in patients with type 2 diabetes.
4. Common side effects include urinary tract infections and genital mycotic infections due to increased glucose in the urine.
5. Farxiga can cause dehydration; therefore, monitoring of renal function and hydration status is essential.

Review Questions

• What mechanism does Farxiga use to lower blood glucose levels?
• For which conditions other than type 2 diabetes is Farxiga approved?
• What are common side effects associated with Farxiga?

Related terms

Sodium-Glucose Cotransporter 2 Inhibitors (SGLT2Is): A class of medications that lower blood sugar by preventing glucose reabsorption in the kidneys.

Type 2 Diabetes:

A chronic condition characterized by insulin resistance and high blood glucose levels.

Heart Failure:

A condition where the heart cannot pump enough blood to meet the body's needs.