Cathflo Activase
from class: Pharmacology for Nurses Definition Cathflo Activase is a thrombolytic agent used to dissolve blood clots in catheters. It contains the active ingredient alteplase, a tissue plasminogen activator (tPA).
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Predict what's on your test 5 Must Know Facts For Your Next Test Cathflo Activase is specifically indicated for the restoration of function to central venous access devices (CVAD) that have been obstructed by clots. The standard dosage for Cathflo Activase in catheter clearance is 2 mg instilled directly into the catheter. It works by converting plasminogen to plasmin, which then degrades fibrin and dissolves the clot. Alteplase has a short half-life of about 5 minutes, necessitating quick action upon administration. Common side effects include bleeding and hypersensitivity reactions. Review Questions What is the primary medical use of Cathflo Activase? How does Cathflo Activase work at the molecular level to dissolve clots? What are potential side effects of using Cathflo Activase?
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