Cardiotoxicity

Definition

Cardiotoxicity is the occurrence of heart muscle damage due to toxic substances, including certain medications. It can lead to serious conditions such as arrhythmias or heart failure.

5 Must Know Facts For Your Next Test

1. Certain antidepressants, particularly tricyclic antidepressants (TCAs), are associated with a higher risk of cardiotoxicity.
2. Cardiotoxicity symptoms can include chest pain, palpitations, shortness of breath, and fatigue.
3. Electrocardiograms (ECGs) are often used to monitor for signs of cardiotoxicity in patients taking high-risk medications.
4. The mechanism of cardiotoxicity in antidepressants can involve inhibition of cardiac ion channels leading to arrhythmias.
5. Early detection and intervention are crucial to managing cardiotoxicity effectively.

Review Questions

• Which class of antidepressants is most commonly associated with cardiotoxicity?
• What are common symptoms indicating potential cardiotoxicity in a patient?
• How is cardiotoxicity typically monitored in patients on high-risk medications?

Related terms

Arrhythmia:

An irregular heartbeat that can result from cardiotoxicity.

Tricyclic Antidepressants (TCAs):

A class of antidepressants known for their potential side effects, including cardiotoxicity.

Electrocardiogram (ECG): A test that records the electrical activity of the heart and is used to detect abnormalities like those caused by cardiotoxicity.