Avastin

Definition

Avastin, also known as Bevacizumab, is a monoclonal antibody that inhibits angiogenesis by blocking vascular endothelial growth factor (VEGF). It is commonly used in the treatment of various cancers and certain eye diseases.

5 Must Know Facts For Your Next Test

1. Avastin works by inhibiting VEGF, which prevents the growth of new blood vessels necessary for tumor growth.
2. It is administered via intravenous infusion, typically in a clinical setting under medical supervision.
3. Common side effects include hypertension, fatigue, and increased risk of bleeding or blood clots.
4. Avastin is often used in combination with other chemotherapy agents for enhanced efficacy.
5. Due to its mechanism of action, Avastin can impair wound healing and should be discontinued before surgery.

Review Questions

• What is the primary mechanism of action of Avastin?
• List three common side effects associated with Avastin.
• Why might Avastin need to be discontinued prior to surgery?

Related terms

Monoclonal Antibodies:

Laboratory-made molecules that can mimic the immune system's ability to fight off harmful pathogens.

VEGF (Vascular Endothelial Growth Factor): A signal protein that stimulates the formation of blood vessels.

Biosimilar Drugs:

Biological products highly similar to already approved reference products with no clinically meaningful differences.