Antisecretory
from class: Pharmacology for Nurses Definition Antisecretory agents are drugs that inhibit the secretion of gastric acid in the stomach. They are primarily used to treat conditions like hyperacidity, peptic ulcers, and gastroesophageal reflux disease (GERD).
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Predict what's on your test 5 Must Know Facts For Your Next Test Antisecretory agents include histamine blockers (H2 blockers) and proton-pump inhibitors (PPIs). Histamine blockers work by blocking histamine H2 receptors on parietal cells in the stomach lining. Proton-pump inhibitors inhibit the enzyme H+/K+ ATPase, which is responsible for acid secretion in the stomach. Common side effects of antisecretory agents can include headache, diarrhea, and abdominal pain. Antisecretory agents are often used in combination with antibiotics to treat Helicobacter pylori infections. Review Questions What are two main classes of antisecretory agents? How do proton-pump inhibitors reduce gastric acid secretion? Name one common side effect associated with antisecretory agents.
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