Alendronate

Definition

Alendronate is a bisphosphonate medication used to treat and prevent osteoporosis by inhibiting bone resorption. It helps increase bone mineral density, reducing the risk of fractures.

5 Must Know Facts For Your Next Test

1. Alendronate must be taken with a full glass of water at least 30 minutes before the first meal or drink of the day to ensure proper absorption.
2. Patients should remain upright for at least 30 minutes after taking Alendronate to reduce the risk of esophageal irritation or ulcers.
3. Common side effects include gastrointestinal issues such as abdominal pain, acid reflux, and constipation.
4. It is contraindicated in patients with abnormalities of the esophagus that delay esophageal emptying, such as stricture or achalasia.
5. Alendronate works by binding to hydroxyapatite in bone, inhibiting osteoclast activity and decreasing bone resorption.

Review Questions

• What is the primary use of Alendronate in clinical practice?
• Why must patients remain upright for at least 30 minutes after taking Alendronate?
• List two common gastrointestinal side effects associated with Alendronate.

Related terms

Bisphosphonates:

A class of drugs that prevent the loss of bone density by inhibiting osteoclast-mediated bone resorption.

Osteoporosis:

A condition characterized by weakened bones and an increased risk of fractures.

Hydroxyapatite:

A naturally occurring mineral form of calcium apatite found in bones and teeth.