Lactams

Definition

Lactams are cyclic amides formed when a carboxylic acid group on one part of a molecule reacts with an amine group on another part of the same molecule, resulting in ring closure. They are important in organic chemistry because they serve as the core structure for many synthetic and naturally occurring compounds.

Related terms

Carboxylic Acid:

An organic compound containing a carboxyl group (COOH), which is fundamental to forming lactams through its reaction with an amine.

Amide:

A functional group characterized by a carbonyl group attached to a nitrogen atom, which is key in the structure of lactams.

Nucleophilic Acyl Substitution:

A reaction mechanism where an electron-rich nucleophile attacks an electron-deficient acyl compound, leading to substitution or transformation; this process is pivotal in the formation of lactams from carboxylic acids and amines