Dieckmann cyclization reaction

Definition

The Dieckmann cyclization reaction is an intramolecular chemical process in Organic Chemistry where a dicarboxylic acid ester undergoes condensation to form a cyclic β-keto ester under the influence of a base. It serves as a specific example of intramolecular Claisen condensation, crucial for synthesizing five- or six-membered rings.

Related terms

Claisen Condensation:

A reaction where two esters or one ester and another carbonyl compound react in the presence of a strong base to form a β-keto ester or β-diketone.

Esterification:

A chemical reaction that forms an ester as the product from an alcohol and an acid (either carboxylic acid or inorganic acid) by removing water (dehydration).

Base Catalysis: A type of catalysis where the rate of a chemical reaction is increased by the addition of a base, which acts to remove protons (H⁺ ions) and facilitate bond formation between reactants