Dieckmann cyclization

Definition

Dieckmann cyclization is a chemical reaction where a diester undergoes intramolecular condensation in the presence of a base, resulting in the formation of a cyclic β-keto ester. It's a specific type of intramolecular Claisen condensation that is useful for synthesizing five or six-membered rings.

Related terms

Intramolecular reaction: A chemical reaction where the reactants are within the same molecule, leading to the formation of cyclic structures.

Claisen condensation: A carbon-carbon bond forming reaction between two esters or one ester and another carbonyl compound in the presence of a strong base, producing a β-keto ester or β-diketone.

Base catalysis: A process where a base speeds up a chemical reaction by making it easier for electrons to move around, crucial for reactions like Dieckmann cyclization