Valacyclovir

Definition

Valacyclovir is an antiviral medication used to treat infections caused by herpes viruses, including herpes simplex virus (HSV) and varicella-zoster virus (VZV). It is a prodrug that is converted into acyclovir in the body, which then inhibits viral DNA polymerase.

5 Must Know Facts For Your Next Test

1. Valacyclovir is effective against HSV-1, HSV-2, and VZV.
2. It works by inhibiting viral DNA synthesis, preventing the virus from replicating.
3. Common indications include treatment of cold sores, genital herpes, and shingles.
4. Valacyclovir has better oral bioavailability compared to acyclovir.
5. It can be used for both acute treatment and chronic suppression of recurrent herpes infections.

Review Questions

• What viruses are commonly treated with valacyclovir?
• How does valacyclovir function at the molecular level to inhibit viral replication?
• Why might a physician choose valacyclovir over acyclovir for a patient?

Related terms

Acyclovir:

An antiviral drug that directly inhibits viral DNA polymerase after being phosphorylated by viral thymidine kinase.

Herpes Simplex Virus (HSV): A type of virus that causes infections in various parts of the body, most commonly affecting the mouth or genitals.

Varicella-Zoster Virus (VZV): The virus responsible for causing both chickenpox and shingles.