Triclabendazole

Definition

Triclabendazole is an antiparasitic drug primarily used to treat infections caused by liver flukes, specifically Fasciola hepatica and Fasciola gigantica. It inhibits the enzyme systems of the flukes, leading to their death.

5 Must Know Facts For Your Next Test

1. Triclabendazole is effective against both immature and adult stages of liver flukes.
2. It works by inhibiting the synthesis of microtubules in the parasites.
3. The drug is typically administered orally and has good bioavailability.
4. Triclabendazole is considered safe, with mild and transient side effects like nausea and headache.
5. It is on the World Health Organization's List of Essential Medicines.

Review Questions

• What stages of liver flukes does triclabendazole target?
• How does triclabendazole work at the cellular level in parasites?
• What are common side effects associated with triclabendazole?

Related terms

Fascioliasis:

An infection caused by liver flukes, commonly treated with triclabendazole.

Anthelmintic:

A type of medication that expels or destroys parasitic worms.

Bioavailability:

The degree to which a drug becomes available to the target tissue after administration.