Streptokinase

Definition

Streptokinase is an enzyme produced by certain strains of streptococci bacteria. It functions by breaking down blood clots through the conversion of plasminogen to plasmin.

5 Must Know Facts For Your Next Test

1. Streptokinase is primarily produced by Group A Streptococcus (GAS) bacteria.
2. It plays a significant role in the spread of bacterial infections by breaking down fibrin barriers.
3. Streptokinase is used clinically as a thrombolytic agent to treat conditions like myocardial infarction and pulmonary embolism.
4. The enzyme aids bacterial invasiveness in skin and eye infections, facilitating deeper tissue penetration.
5. In respiratory tract infections, streptokinase may contribute to severe outcomes by enhancing bacterial dissemination.

Review Questions

• What type of bacteria primarily produces streptokinase?
• How does streptokinase facilitate the spread of bacterial infections?
• List one clinical application of streptokinase.

Related terms

plasminogen: A precursor protein that is converted into plasmin, which dissolves blood clots.

Group A Streptococcus (GAS): A category of bacteria known for causing various infections including strep throat and skin infections.

thrombolytic agent: A drug used to break up or dissolve blood clots.