Selective IgA deficiency

Definition

Selective IgA deficiency is an immune disorder characterized by a lack of Immunoglobulin A (IgA) antibodies, which play a crucial role in mucosal immunity. It is the most common primary immunodeficiency.

5 Must Know Facts For Your Next Test

1. Patients with selective IgA deficiency are more susceptible to respiratory and gastrointestinal infections.
2. This condition can be asymptomatic or present with recurrent infections, allergies, and autoimmune diseases.
3. It is often diagnosed through blood tests showing low or absent levels of IgA while other immunoglobulins remain normal.
4. Genetic factors are believed to contribute to the development of selective IgA deficiency.
5. There is no specific treatment for selective IgA deficiency; management focuses on treating infections and associated conditions.

Review Questions

• What type of infections are individuals with selective IgA deficiency more prone to?
• How is selective IgA deficiency typically diagnosed?
• Are there any specific treatments available for selective IgA deficiency?

Related terms

Primary Immunodeficiency: Disorders where part of the body's immune system is missing or does not function properly.

Immunoglobulin A (IgA): An antibody that plays a critical role in mucosal immunity, found in mucous membranes lining the respiratory and gastrointestinal tracts.

Autoimmune Disease: Conditions where the immune system mistakenly attacks the body's own tissues.