Pseudomurein is a structural polysaccharide found in the cell walls of some archaea. It is similar to peptidoglycan in bacteria but has different chemical linkages and sugar components.
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Pseudomurein consists of repeating units of N-acetyltalosaminuronic acid and N-acetylglucosamine.
Unlike peptidoglycan, pseudomurein has ฮฒ(1โ3) glycosidic bonds instead of ฮฒ(1โ4) glycosidic bonds.
Pseudomurein is resistant to lysozyme, an enzyme that breaks down bacterial cell walls containing peptidoglycan.
It provides structural support to archaeal cell walls, particularly in methanogens.
The presence of pseudomurein distinguishes certain archaea from bacteria and other archaea that do not possess it.