PPP

Definition

The Pentose Phosphate Pathway (PPP) is an alternative pathway for the oxidation of glucose. It generates NADPH and ribose-5-phosphate, crucial for anabolic reactions and nucleotide synthesis.

5 Must Know Facts For Your Next Test

1. The PPP operates in the cytoplasm and is divided into oxidative and non-oxidative phases.
2. NADPH produced in the PPP is essential for reductive biosynthesis and maintaining the cellular redox state.
3. Ribose-5-phosphate produced in the PPP is a precursor for nucleotide and nucleic acid synthesis.
4. The oxidative phase of the PPP produces two molecules of NADPH per glucose-6-phosphate molecule oxidized.
5. Transketolase and transaldolase are key enzymes in the non-oxidative phase, facilitating the interconversion between sugars.

Review Questions

• What are the primary products of the Pentose Phosphate Pathway?
• Which phase of the PPP generates NADPH?
• Name two key enzymes involved in the non-oxidative phase of the PPP.

Related terms

Glycolysis:

A metabolic pathway that converts glucose into pyruvate, generating ATP and NADH.

NADPH:

A coenzyme involved in anabolic reactions, acting as a reducing agent.

Ribose-5-phosphate: A sugar phosphate used in nucleotide and nucleic acid synthesis.