Phagocytes

Definition

Phagocytes are immune cells that engulf and digest pathogens, cellular debris, and foreign particles. They play a crucial role in both innate and adaptive immunity.

5 Must Know Facts For Your Next Test

1. Phagocytes include cells such as macrophages, neutrophils, and dendritic cells.
2. They are essential for presenting antigens to T-cells, thus initiating adaptive immune responses.
3. Phagocytosis involves the recognition of pathogen-associated molecular patterns (PAMPs) through pattern recognition receptors (PRRs).
4. Macrophages can be activated by cytokines to enhance their phagocytic activity.
5. Deficiencies in phagocyte function can lead to increased susceptibility to infections and are associated with certain immunodeficiency disorders.

Review Questions

• Which types of immune cells are considered phagocytes?
• How do phagocytes contribute to the activation of the adaptive immune system?
• What mechanisms do phagocytes use to recognize and engulf pathogens?

Related terms

Macrophages:

Large phagocytic cells derived from monocytes that reside in tissues.

Neutrophils:

A type of white blood cell that is one of the first responders to infection sites.

Antigen-Presenting Cells (APCs):

Cells like dendritic cells that process and present antigens to T-cells to initiate an adaptive immune response.