Negri bodies

Definition

Negri bodies are intracytoplasmic inclusions found in neurons, typically associated with rabies virus infection. They serve as a diagnostic marker for the disease.

5 Must Know Facts For Your Next Test

1. Negri bodies are predominantly found in the pyramidal cells of the hippocampus and Purkinje cells of the cerebellum.
2. They are eosinophilic, meaning they stain pink with eosin dye during histological examination.
3. Negri bodies were first described by Adelchi Negri in 1903.
4. Their presence is considered pathognomonic for rabies, meaning they are a definitive indicator of the disease.
5. Detection of Negri bodies can be accomplished through brain biopsies or post-mortem examination.

Review Questions

• Where in the body are Negri bodies most commonly found?
• What staining characteristic do Negri bodies exhibit under a microscope?
• Why are Negri bodies considered pathognomonic for rabies?

Related terms

Rabies Virus:

A neurotropic virus that causes rabies, a severe viral encephalitis.

Eosinophilic: Refers to tissue components that stain pink with eosin dye, commonly used in histology.

Purkinje Cells: Large neurons located in the cerebellar cortex involved in motor control.