Nafcillin

Definition

Nafcillin is a beta-lactam antibiotic belonging to the penicillin class, primarily used for treating infections caused by penicillinase-producing staphylococci. It is commonly administered intravenously due to its poor absorption when taken orally.

5 Must Know Facts For Your Next Test

1. Nafcillin is effective against Staphylococcus aureus strains that produce beta-lactamase, an enzyme that deactivates many other penicillins.
2. It is often used for serious bacterial infections such as endocarditis, osteomyelitis, and septicemia.
3. Nafcillin works by inhibiting the synthesis of bacterial cell walls, leading to cell lysis and death.
4. Unlike many other antibiotics, nafcillin does not require dosage adjustment in patients with renal impairment.
5. Common side effects include hypersensitivity reactions, gastrointestinal disturbances, and potential liver function abnormalities.

Review Questions

• What types of bacteria is nafcillin particularly effective against?
• For what serious infections might a doctor prescribe nafcillin?
• Why does nafcillin not require dosage adjustment in patients with renal impairment?

Related terms

Beta-lactamase: An enzyme produced by certain bacteria that deactivates beta-lactam antibiotics like penicillins.

Endocarditis:

An infection of the inner lining of the heart chambers and valves typically caused by bacteria.

Septicemia:

A life-threatening infection where bacteria enter the bloodstream and spread throughout the body.