Mast cells

Definition

Mast cells are a type of white blood cell that plays a critical role in the immune system by releasing histamine and other chemicals during inflammatory and allergic responses. They are primarily found in connective tissues, including the skin, lungs, and digestive tract.

5 Must Know Facts For Your Next Test

1. Mast cells contain granules rich in histamine and heparin.
2. They play a key role in both innate and adaptive immune responses.
3. Activation of mast cells can trigger immediate hypersensitivity reactions, such as anaphylaxis.
4. Mast cells express high-affinity receptors for IgE antibodies.
5. They release various cytokines and chemokines that modulate the immune response.

Review Questions

• What substances do mast cells release during an inflammatory response?
• How do mast cells contribute to hypersensitivity reactions?
• In which tissues are mast cells primarily found?

Related terms

Histamine: A compound released by mast cells that causes vasodilation and increased permeability of blood vessels.

IgE Antibodies: A class of antibodies that bind to allergens and trigger histamine release from mast cells.

Anaphylaxis: A severe, potentially life-threatening allergic reaction triggered by mast cell activation.