Liver cancer

Definition

Liver cancer is a malignant tumor that originates in the liver cells, often caused by chronic infections with hepatitis B or C virus. It can disrupt liver function and spread to other parts of the body.

5 Must Know Facts For Your Next Test

1. Hepatitis B and C are significant microbial pathogens that increase the risk of liver cancer.
2. Chronic inflammation from viral infections leads to cellular damage and mutations in liver cells.
3. Virulence factors of Hepatitis B and C, such as surface proteins, help the viruses evade the immune system.
4. Liver cancer can be promoted by the integration of viral DNA into host cell genomes, causing genetic instability.
5. Understanding the molecular mechanisms of these viruses aids in developing targeted treatments for liver cancer.

Review Questions

• How do Hepatitis B and C viruses contribute to the development of liver cancer?
• What role do virulence factors play in the pathogenesis of liver cancer?
• Why is chronic inflammation a significant factor in liver carcinogenesis?

Related terms

Hepatitis B Virus:

A virus that infects the liver and can lead to chronic hepatitis, cirrhosis, and liver cancer.

Hepatitis C Virus:

A bloodborne virus that causes chronic infection leading to severe liver disease including cirrhosis and hepatocellular carcinoma.

Virulence Factors:

Molecules produced by pathogens that contribute to their ability to cause disease.