Human herpesvirus 4 (HHV-4)
from class: Microbiology Definition Human herpesvirus 4 (HHV-4), also known as Epstein-Barr virus (EBV), is a member of the herpesvirus family. It primarily infects B cells and epithelial cells, causing infectious mononucleosis and being implicated in various cancers.
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Predict what's on your test 5 Must Know Facts For Your Next Test HHV-4 is commonly transmitted through saliva, often referred to as the 'kissing disease.' Primary infection with HHV-4 can lead to infectious mononucleosis, characterized by fever, sore throat, and swollen lymph nodes. HHV-4 has been associated with several types of cancer, including Burkitt's lymphoma and nasopharyngeal carcinoma. The virus remains latent in B cells for life after primary infection, potentially reactivating under certain conditions. Diagnosis of HHV-4 infection is often confirmed through serological tests detecting specific antibodies or PCR testing for viral DNA. Review Questions What are the common symptoms associated with primary HHV-4 infection? Through which bodily fluid is HHV-4 most commonly transmitted? In which cells does HHV-4 establish latency?
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