Compound 606

Definition

Compound 606, also known as Salvarsan or arsphenamine, was the first synthetic antimicrobial drug. It was developed by Paul Ehrlich in the early 20th century to treat syphilis.

5 Must Know Facts For Your Next Test

1. Compound 606 was discovered by Paul Ehrlich and his colleague Sahachiro Hata in 1909.
2. It marked the beginning of the modern era of chemotherapy and antimicrobial therapy.
3. Salvarsan is an organoarsenic compound, which was revolutionary at its time for targeting specific pathogens.
4. The discovery of Compound 606 led to the development of other arsenic-based drugs.
5. Despite its effectiveness, Salvarsan had significant side effects due to its arsenic content.

Review Questions

• Who were the key scientists involved in the discovery of Compound 606?
• What disease was Compound 606 primarily used to treat?
• Why is Compound 606 considered a milestone in the history of chemotherapy?

Related terms

Chemotherapy:

The use of chemical substances to treat disease, especially cancer.

Paul Ehrlich:

A German scientist who pioneered the concept of selective toxicity and discovered Compound 606.

Syphilis:

A sexually transmitted infection caused by the bacterium Treponema pallidum, historically treated with Salvarsan.