Arthritis is an inflammatory condition affecting the joints, characterized by pain and stiffness. It can be associated with immune system dysfunction, particularly in autoimmune forms.
5 Must Know Facts For Your Next Test
Rheumatoid arthritis (RA) is an autoimmune disorder where the immune system mistakenly attacks joint tissues.
Cytokines such as TNF-alpha and IL-1 play crucial roles in the inflammation seen in RA.
Autoantibodies like rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPAs) are often present in RA patients.
Certain infections can trigger reactive arthritis, a form of arthritis linked to immune response against pathogens.
The synovial membrane becomes inflamed in RA, leading to pannus formation which damages cartilage and bone.
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Related terms
Autoimmunity: A condition where the immune system attacks the body's own cells.