Octamer boxes

Definition

Octamer boxes are DNA sequence elements found in the promoter region of genes. They play a crucial role in the regulation of gene transcription by binding specific transcription factors called octamer-binding proteins.

5 Must Know Facts For Your Next Test

1. Octamer boxes have a consensus sequence of ATTTGCAT.
2. They are typically located upstream of the start site of transcription.
3. Octamer boxes are binding sites for Oct-1 and Oct-2 transcription factors.
4. They are involved in the regulation of both housekeeping and tissue-specific genes.
5. Mutation or deletion of octamer boxes can lead to reduced or altered gene expression.

Review Questions

• What is the consensus sequence for an octamer box?
• Which transcription factors bind to octamer boxes?
• How do mutations in octamer boxes affect gene expression?

Related terms

Promoter:

A region of DNA where transcription of a gene is initiated.

Transcription Factor: A protein that binds to specific DNA sequences to regulate the expression of genes.

Consensus Sequence: A sequence of DNA having similar structure and function in different organisms.