Inositol phospholipids
from class: General Biology I Definition Inositol phospholipids are a group of lipids that play critical roles in cell signaling by acting as substrates for the production of secondary messengers. They are located primarily in the inner leaflet of the plasma membrane.
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Predict what's on your test 5 Must Know Facts For Your Next Test Inositol phospholipids can be phosphorylated to generate various forms, such as PIP2 and PIP3. Phosphatidylinositol 4,5-bisphosphate (PIP2) is a key substrate for the enzyme phospholipase C (PLC). The hydrolysis of PIP2 by PLC produces two important secondary messengers: diacylglycerol (DAG) and inositol trisphosphate (IP3). Inositol phosphates like IP3 can trigger the release of calcium ions from intracellular stores. PIP3, another form of inositol phospholipid, is involved in activating protein kinase B (Akt), which plays a crucial role in cell growth and survival. Review Questions What are the secondary messengers produced from the hydrolysis of PIP2? How does IP3 contribute to signal propagation within cells? Which enzyme converts PIP2 into DAG and IP3?
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