Induced fit

Definition

Induced fit is a model explaining how enzymes undergo conformational changes upon substrate binding, enhancing the enzyme's catalytic activity. This dynamic adjustment increases the specificity and efficiency of enzyme-substrate interactions.

5 Must Know Facts For Your Next Test

1. Induced fit describes how an enzyme changes shape to better accommodate the substrate.
2. Conformational change in the enzyme enhances its ability to catalyze chemical reactions.
3. The induced fit model contrasts with the lock-and-key model, which suggests a static interaction.
4. Enzyme-substrate complexes formed through induced fit are more specific and efficient.
5. The concept of induced fit helps explain why enzymes are highly selective for their substrates.

Review Questions

• What happens to an enzyme's shape when it binds to a substrate according to the induced fit model?
• How does the induced fit model enhance enzyme specificity?
• In what way does the induced fit model differ from the lock-and-key model?

Related terms

ActiveSite: The region on an enzyme where substrate molecules bind and undergo a chemical reaction.

Substrate: The substance on which an enzyme acts during a biochemical reaction.

Catalysis: The process by which an enzyme speeds up a chemical reaction without being consumed in the process.