CAAT box

Definition

The CAAT box is a conserved nucleotide sequence found in the promoter region of eukaryotic genes. It plays a crucial role in the binding of transcription factors, enhancing gene expression efficiency.

5 Must Know Facts For Your Next Test

1. The CAAT box is typically located about 75-80 base pairs upstream of the transcription start site.
2. It is recognized and bound by specific transcription factors such as CTF (CAAT-binding transcription factor).
3. Mutations in the CAAT box can significantly reduce or completely inhibit gene transcription.
4. The sequence consensus for the CAAT box is 'GGCCAATCT'.
5. It works synergistically with other promoter elements like the TATA box to ensure proper initiation of transcription.

Review Questions

• Where is the CAAT box typically located relative to the transcription start site?
• Which type of protein binds specifically to the CAAT box to enhance gene expression?
• What impact do mutations in the CAAT box have on gene transcription?

Related terms

TATA Box: A DNA sequence found in the promoter region that helps initiate transcription by binding RNA polymerase II.

Transcription Factors: Proteins that bind to specific DNA sequences to regulate gene expression.

Promoter Region: A region of DNA where transcription of a gene is initiated, containing various regulatory elements like the TATA and CAAT boxes.