Medication: In the context of combination therapy for depression, medication refers to the use of antidepressant drugs to alleviate symptoms. Antidepressants work by altering brain chemistry to improve mood.
Psychotherapy: Psychotherapy involves talking with a trained therapist or counselor to explore thoughts, emotions, and behaviors related to depression. It aims at identifying underlying causes and developing coping strategies.
Treatment-resistant depression (TRD): TRD refers to cases where individuals do not experience significant improvement in depressive symptoms despite receiving adequate treatment with either medication or psychotherapy alone. Combination therapy may be recommended for TRD patients.